We will be running operating system upgrades for the server that powers many of our data APIs (portaldev.sph.umich.edu). We have scheduled some downtime to install it next Friday Nov 13 @ 5:30PM (eastern US time). If you use interactive LocusZoom.js plots, you may notice either downtime or partial errors during this window, as many installations use our shared infrastructure for information like recombination rate, LD, and genes. Sample sites affected may include PheWeb, my.locuszoom.org, and certain parts of pages on the T2D Knowledge Portal.
This outage is expected to last < 3 hrs, and will not affect users of the standalone python locuszoom. We apologize for the inconvenience, and aim to make downtime as rare as possible.
--Andy Boughton
We have released LocusZoom.js v0.12, with many new features and improvements. User-facing additions include interactive filtering of displayed elements (eg a dropdown menu to control which genes/pseudogenes are shown), a "save as PNG" feature, and updated default datasets for genes and GWAS catalog variants. For GRCh38 datasets, plots will now default to using a new and improved version of the 1000G LD reference panel that is based on deep whole-genome sequencing.
For developers, there are a number of additional features, but also some internal changes that may break existing sites. See the release notes for details.
All of the new features in LocusZoom.js 0.12.0 are also available in our plot-your-own-data tools for immediate use (LocalZoom and my.locuszoom.org). (try a demo)
Lastly, the upload service has been enhanced with a new feature: all newly uploaded datasets will now annotate provided SNPs with rsIDs from dbSNP where possible (based on chrom/pos/ref/alt information). If a match is found, the rsID will appear in the "top hits" table as well as association scatter plot tooltips.
--Andy Boughton
In our first two months, the new my.locuszoom.org upload service has been used by people in 48 countries. To thank our users, we have recently added several new features to the the site, including "nearest gene" annotations, user-selectable LD reference populations (from 1000G data), and a "batch view" to browse regions of interest more easily. We continue to improve our handling of diverse file formats, and welcome feedback or questions as always.
Following our commitment to reusable tools, the new LD chooser may be used with any site that uses LocusZoom.js (courtesy of the new v0.10 release). To further support custom LocusZoom usages, we have also refreshed the API documentation in response to feedback and questions.
--Andy Boughton
A brief advance notice on planned downtime that might affect some LocusZoom users: We have recently received some new hardware for the server that powers many of our data APIs (portaldev.sph.umich.edu). We have scheduled some downtime to install it next Wednesday Nov 6 @ 2PM (eastern US time). If you use interactive LocusZoom.js plots, you may notice either downtime or partial errors during this window, as many installations use our shared infrastructure for information like recombination rate, LD, and genes. Sample sites affected may include PheWeb, my.locuszoom.org, and certain parts of pages on the T2D Knowledge Portal.
This outage is expected to last < 3 hrs, and will not affect users of the standalone python locuszoom. We apologize for the inconvenience: while we aim to make downtime very rare, this one will help us to better serve our users with new features going forward.
--Andy Boughton
We are happy to announce the newest stage in our efforts to support interactive, exploratory GWAS plots: the new my.locuszoom.org upload-to-plot service. This new service generates fully interactive plots, with no limits on the number of loci you can explore. It also adds new features such as Manhattan and QQ plots, annotation options, and calculations that put findings in context. The default annotations support human datasets in builds GRCh37 or GRCh38; more annotation features are planned soon. Studies may be kept private, shared only with collaborators, or shared publicly.
We are still working on adding features to the new version. For the time being, this old site will remain active, but it is not actively maintained. We encourage you to try our new offerings ("LocalZoom" for sensitive data, and my.locuszoom.org for the full set of exploratory analysis features). We will be at ASHG to discuss these services, and any other LocusZoom.js questions you may have! (Poster 1660T, 3-4pm Thursday October 17)
--Andy Boughton
We have recently been working on ways to simplify generating an interactive plot with your own data, using only a web browser, without the need for a server. Our "LocalZoom" tool is the first visible step in this process- it is currently in beta, but can be helpful for exploratory analysis.
Features:--Andy Boughton
With its latest release (v0.4.8), LocusZoom.js now has built-in support for display of annotation/BED tracks. You can also see and work with annotation track data now on the Interactive Plot page.
--Christopher Clark
Some members of the LocusZoom team will be at the American Society of Human Genetics conference in Vancouver, Canada from October 18-22. This will include the presentation of a poster describing the new interactive LocusZoom.js:
The poster will be located at 1829T in the Bioinformatics and Computational Approaches section. See and download the full resolution PDF of the poster here.
If you find yourself at ASHG this October please stop by! The poster session will be from 2PM-3PM on Thursday, October 20.
--Christopher Clark
Recently the UM/CSG team began work on LocusZoom.js, a way of making LocusZoom embeddable and interactive.
Starting from scratch we developed a LocusZoom semi-clone entirely in Javascript with forward thinking into how it could be more extensible. Below is a flat image showing what a plot generated in LocusZoom.js can look like today:
Being built for the web, interaction with the new LocusZoom.js is fundamentally different from how you would interact with Original LocusZoom (built in Python and R for command-line operation). To see for yourself begin by interactively plotting published GWAS results. Add arbitrarily many studies and navigate around the genome with your mouse. LocusZoom.js has not yet been hooked up to a form to upload your data here on this website, but it is open source and heavily documented so you can build your own applications with it. See the documentation and get the source code to get started!
The original LocusZoom (Python/R) for generating single/batch plots of your data or single plots of published GWAS datais still available here and will continue to be.
Please tell us what you think! Post your questions and feedback on the LocusZoom Message Board.
--Christopher Clark
We are pleased to announce that our paper on LocusZoom has been published!
Reference: Pruim RJ*, Welch RP*, Sanna S, Teslovich TM, Chines PS, Gliedt TP, Boehnke M, Abecasis GR, Willer CJ. (2010) LocusZoom: Regional visualization of genome-wide association scan results. Bioinformatics 2010 September 15; 26(18): 2336.2337.
--Terry Gliedt
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